The St. Louis metropolitan area continues to demonstrate strong economic momentum, ranking 16th nationally among U.S. metros in Gross Domestic Product (GDP). GDP for the St. Louis metro is $226.5 billion, an increase of 7.1% year-over-year. St. Louis is a prominent Midwestern industrial and innovation hub, driven by its strategic centralized U.S. location, nationally ranked freight infrastructure, resilient workforce, abundant industrial space, and favorable business climate. The St. Louis metro has a growing and diversified economy based in the industries of logistics, advanced manufacturing, financial services, bioscience, and education and health care. The region houses the headquarters for over 20 large corporations and has had major expansions in 2025. Boeing and Bayer added over 3,500 jobs in the second quarter of 2025, and Amazon’s new regional distribution center, along with World Wide Technology’s headquarters growth, are expected to generate 4,000 new jobs by year’s end.
The St. Louis region is rapidly emerging as a national hub for geospatial technology, anchored by a $1.7 billion federal investment and the launch of the Taylor Geospatial Institute. With more than 10,000 professionals in geospatial roles and a projected $5 billion economic impact, this sector is drawing in new firms and fueling innovation.